Endocrine Abstracts

The human Short-chain alcohol Dehydrogenase Reductase (SDR) superfamily of oxoreductase enzymes regulate important endocrine hormones. Two SDR members, 11b-hydroxysteroid dehydrogenase (11bHSD) 1 & 2 have key roles in the pre-nuclear receptor modification of glucocorticoid steroids, thereby contributing to regulation of fluid homeostasis, blood pressure, metabolic pathways and brain function. We have recently characterised a third structurally related HSD enzyme, 11B-HSD1L...